Currently, there are no treatments for obesity that directly target and eliminate fat cells (adipocytes). Dr. Stanley Riddell, in collaboration with colleagues at the NIH, have demonstrated that an anti-ROR1 CAR T is able to specifically recognize mature adipocytes and exert cytolytic activity. Interestingly, the only normal tissue that expresses the ROR1 protein on the surface of the cell is preadipocytes, progenitor fat cells, which make them an ideal therapeutic target for immunotherapy. Experiments in non-human primates also demonstrated the favorable safety profile of administering anti-ROR1 CAR T cells in vivo.
- Method of reducing adipocytes by targeting ROR1 with CAR T cells
- Novel mechanism for treatment of obesity by selectively targeting adipocytes
Stanley Riddell, MD, Clinical Research Division
Burke O’Reilly Family Endowed Chair in Immunotherapy