Researchers led by Dr. Stephen Tapscott at Fred Hutch and Dr. Bradley Cairns at the University of Utah have uncovered novel mechanistic understandings of DUX family member proteins and their role in embryonic genome activation (EGA) as recently published in Nature Genetics. These studies suggest novel methods to improve cellular reprogramming. The potential to activate the transcriptional totipotent program has applications that include reproductive biology and regenerative medicine. This method might also be leveraged to enhance somatic cell nuclear transfer (SCNT).
Activate transcription of genes associated with a more totipotent early embryonic stem cell state to enhance the potential of iPS cells
Activate transcription of genes associated with a more totipotent early embryonic stem cell state to enhance SCNT
Increased efficiency of SCNT
Ability of DUX programmed cells to differentiate into multiple lineages, including extraembryonic tissues
US patent pending
The market for global regenerative medicine is expected to reach $49.1B by 2021. The cell therapy segment is expected to dominate the market. Drivers of this market include limitations on the ability to engineer stem cells and tissues. The technology developed by Fred Hutch and the University of Utah has multiple applications and could be leveraged to improve the totipotent state of engineered cell products.
Stephen Tapscott, MD, PhD, Human Biology and Clinical Research Divisions
Bradley Cairns, PhD, Dept. of Oncologocial Sciences, University of Utah