Dr. Roland Strong and Dr. Martin Prlic have developed a multimeric NKG2D decoy that will bind all NKG2D ligands and block the NKG2D pathway. NKG2D is a receptor expressed by immune cells which activates the immune cell upon ligand binding. While stimulation of NKG2D can be beneficial in some circumstances, its activation is associated with several autoimmune and inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and graft versus host disease (GVHD). NKG2D stimulation can also dampen the effectiveness of vaccine administrations. Blocking NKG2D stimulation can reduce immune cell activation as a treatment for autoimmune diseases, and for increasing vaccine efficacy.
Therapeutic for autoimmune and inflammatory diseases
Blocks NKG2D immune response
Pan-NKG2D ligand masking through multiple ligand binding positions allows for lower dose with single therapeutic, in contrast with antibody-based therapeutics
Estimated that 50 million Americans have an autoimmune disease. In 2001, National Institutes of Allergy and Infectious Diseases (NIAID) estimated that annual autoimmune disease treatment costs were greater than $100 billion.
Roland Strong, PhD, Vaccine and Infectious Diseases Division
Veronika Groh-Spies, MD, Clinical Research Division
Thomas Spies, PhD, Clinical Research Division
Martin Prlic, PhD, Vaccine and Infectious Diseases Division